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Submit ReviewDiclofenac sodium salt
说明： Cyclooxygenase inhibitor; NSAID
化学名： 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
纯度： ≥99% (HPLC)
生物活性 for Diclofenac sodium salt
Diclofenac sodium salt is a nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50 values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).
技术数据 for Diclofenac sodium salt
| 分子量 | 318.13 |
| 公式 | C14H10Cl2NNaO2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 15307-79-6 |
| PubChem ID | 5018304 |
| InChI Key | KPHWPUGNDIVLNH-UHFFFAOYSA-M |
| Smiles | [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Diclofenac sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 15.91 | 50 | |
| DMSO | 31.81 | 100 |
制备储备液 for Diclofenac sodium salt
以下数据基于产品分子量 318.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.72 mL | 31.43 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.29 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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产品说明书 for Diclofenac sodium salt
参考文献 for Diclofenac sodium salt
参考文献是支持产品生物活性的出版物。
Warner et al (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc.Natl.Acad.Sci.USA 96 7563 PMID: 10377455
Bort et al (1998) Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J.Pharmacol.Exp.Ther. 288 65 PMID: 9862754
Laneuville et al (1994) Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J.Pharmacol.Exp.Ther. 271 927 PMID: 7965814
If you know of a relevant reference for Diclofenac sodium salt, please let us know.
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关键词: Diclofenac sodium salt, Diclofenac sodium salt supplier, nsaids, non-steroidal, anti-inflammatories, anti-inflammatory, cox-1, cox-2, cyclooxygenase, inhibitors, inhibits, Cyclooxygenase, 4454, Tocris Bioscience
1 篇 Diclofenac sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Diclofenac sodium salt 的部分引用包括：
Timothy S et al (2021) Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. J Immunol 207 1275-1287 PMID: 34389624
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