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Submit ReviewDihydrexidine hydrochloride
说明： Selective D1-like agonist
化学名： (±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Dihydrexidine hydrochloride
Dihydrexidine hydrochloride is an a potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.
许可信息
Sold under license, US Patent 5,047,536
技术数据 for Dihydrexidine hydrochloride
| 分子量 | 303.79 |
| 公式 | C17H17NO2.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 137417-08-4 |
| PubChem ID | 11403931 |
| InChI Key | IJYUPBNUPIRQEP-SATBOSKTSA-N |
| Smiles | OC1=C(O)C=C(CC[C@]3([H])[C@@]([H])2C4=C(C=CC=C4)CN3)C2=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Dihydrexidine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 3.04 | 10 | |
| DMSO | 15.19 | 50 |
制备储备液 for Dihydrexidine hydrochloride
以下数据基于产品分子量 303.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.58 mL | 32.92 mL | 65.83 mL |
| 2.5 mM | 1.32 mL | 6.58 mL | 13.17 mL |
| 5 mM | 0.66 mL | 3.29 mL | 6.58 mL |
| 25 mM | 0.13 mL | 0.66 mL | 1.32 mL |
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产品说明书 for Dihydrexidine hydrochloride
参考文献 for Dihydrexidine hydrochloride
参考文献是支持产品生物活性的出版物。
Brewster et al (1990) Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective DA D1 full agonist. J.Med.Chem. 33 1756 PMID: 1971308
Kholi et al (1993) Dihydrexidine: a new potent peripheral DA D1 receptor agonist. Eur.J.Pharmacol. 235 31 PMID: 8100195
Lovenberg et al (1989) Dihydrexidine, a novel selective high potency, full DA D-1 receptor agonist. Eur.J.Pharmacol. 166 111 PMID: 2572425
Taylor et al (1991) Dihydrexidine, a full DA D1 agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 199 389 PMID: 1680717
If you know of a relevant reference for Dihydrexidine hydrochloride, please let us know.
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关键词: Dihydrexidine hydrochloride, Dihydrexidine hydrochloride supplier, Selective, D1-like, agonists, Dopamine, Receptors, D5, dopaminergic, D1, and, 0884, Tocris Bioscience
4 篇 Dihydrexidine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Dihydrexidine hydrochloride 的部分引用包括：
Parker and Kooi (2014) Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. J Neurosci 453 42525 PMID: 24583243
Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Anal Biochem 7 624 PMID: 21785426
Gorelova et al (2002) Mechanisms of DA activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex. J Neurophysiol 88 3150 PMID: 12466437
Smith et al (2005) DArgic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron 45 765 PMID: 15748851
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.