Diltiazem hydrochloride

Cat. No. 0685 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Ca_V1.x blocker

化学名： (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Diltiazem hydrochloride

Diltiazem hydrochloride is an antihypertensive and cardioprotective agent; an inhibitor of L-type Ca²⁺ channels.

化合物库 for Diltiazem hydrochloride

Diltiazem hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Diltiazem hydrochloride

分子量	450.98
公式	C₂₂H₂₆N₂O₄S.HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	33286-22-5
PubChem ID	62920
InChI Key	HDRXZJPWHTXQRI-BHDTVMLSSA-N
Smiles	[H][C@]2(C3=CC=C(OC)C=C3)[C@@]([H])(OC(C)=O)C(N(CCN(C)C)C1=CC=CC=C1S2)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Diltiazem hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water		100
	DMSO	45.1	100

制备储备液 for Diltiazem hydrochloride

以下数据基于产品分子量 450.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.09 mL	22.17 mL
5 mM	0.44 mL	2.22 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for Diltiazem hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Diltiazem hydrochloride

参考文献是支持产品生物活性的出版物。

Dagani et al (1989) Effects of dilt. on bioenergetics, K⁺ gradients, and free cytosolic Ca²⁺ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 53 1379 PMID: 2795006

Gandia et al (1996) Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by dilt. Br.J.Pharmacol. 118 1301 PMID: 8818357

Ishibashi et al (1995) Block of P-type Ca²⁺ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 695 88 PMID: 8574653

Kraus et al (1998) Molecular mechanisms of dilt. interaction with L-type Ca²⁺ channels. J.Biol.Chem. 273 27205 PMID: 9765241

Merck Index 12 3247

If you know of a relevant reference for Diltiazem hydrochloride, please let us know.

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关键词: Diltiazem hydrochloride, Diltiazem hydrochloride supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, anti-hypertensive, cardioprotective, Cav1.x, 0685, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Diltiazem hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov