Diphenyleneiodonium chloride

Name: Diphenyleneiodonium chloride
Brand: Tocris Bioscience
SKU: 0504
Rating: 5 (1 reviews)

Cat. No. 0504 5 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： GPR3 agonist; also inhibits NOS and NADPH oxidases

别名： DPI

化学名： [1,1'-Biphenyl]-2,2'-diyliodonium chloride

纯度： ≥99% (HPLC)

说明书

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Diphenyleneiodonium chloride

Diphenyleneiodonium chloride is a GPR3 agonist (EC₅₀ = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca²⁺ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.

技术数据 for Diphenyleneiodonium chloride

分子量	314.55
公式	C₁₂H₈ClI
储存	Desiccate at -20°C
纯度	≥99% (HPLC)
CAS Number	4673-26-1
PubChem ID	2733504
InChI Key	FCFZKAVCDNTYID-UHFFFAOYSA-M
Smiles	[Cl-].c1c2c3ccccc3[i+]c2ccc1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Diphenyleneiodonium chloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	3.14	10

制备储备液 for Diphenyleneiodonium chloride

以下数据基于产品分子量 314.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	31.79 mL	158.96 mL	317.91 mL
0.5 mM	6.36 mL	31.79 mL	63.58 mL
1 mM	3.18 mL	15.9 mL	31.79 mL
5 mM	0.64 mL	3.18 mL	6.36 mL

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产品说明书 for Diphenyleneiodonium chloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Diphenyleneiodonium chloride

参考文献是支持产品生物活性的出版物。

Stuehr et al (1991) Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J. 5 98 PMID: 1703974

Wang et al (1993) Inhibitory actions of diphenyleneiodonium dependent vasodilations in vitro and in vivo. Br.J.Pharmacol. 110 1232 PMID: 7507779

Yea et al (1990) Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase. Biochem.J. 265 95 PMID: 2154184

Tew (1993) Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications. Biochemistry 32 10209 PMID: 8399148

Ye et al (2014) Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. J.Pharmacol.Exp.Ther. 349 437 PMID: 24633425

If you know of a relevant reference for Diphenyleneiodonium chloride, please let us know.

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关键词: Diphenyleneiodonium chloride, Diphenyleneiodonium chloride supplier, Binds, flavoproteins, inhibits, inhibitors, NOS, Nitric, Oxide, synthase, Signaling, Signalling, NADH, NADPH, reductase, oxidase, GPR3, DPI, Other, Oxidase, Orphan, 7-TM, Receptors, 0504, Tocris Bioscience

5 篇 Diphenyleneiodonium chloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Diphenyleneiodonium chloride 的部分引用包括：

Gonsalves et al (2014) Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α. Am J Hematol 89 273 PMID: 24227191

Knight et al (2013) Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. J Clin Invest 123 2981 PMID: 23722903

Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962

Kim et al (2019) Role of miRNA-181a-2-3p in cadmium-induced inflammatory responses of human bronchial epithelial cells. J Thorac Dis 11 3055 PMID: 31463135

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. Cancer Med 153 2031 PMID: 22633978

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