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Submit ReviewDIPPA hydrochloride
说明： Selective and irreversible κ antagonist
化学名： 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for DIPPA hydrochloride
DIPPA hydrochloride is an an irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.
技术数据 for DIPPA hydrochloride
| 分子量 | 484.87 |
| 公式 | C22H23Cl2N3OS.HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 155512-52-0 |
| PubChem ID | 45073425 |
| InChI Key | BNWYENYHNOESCX-ZMBIFBSDSA-N |
| Smiles | ClC1=C(Cl)C=C(CC(N([C@@](CN3CCCC3)([H])C2=CC=CC(N=C=S)=C2)C)=O)C=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DIPPA hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 14.55 | 30 | |
| DMSO | 24.24 | 50 |
制备储备液 for DIPPA hydrochloride
以下数据基于产品分子量 484.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.12 mL | 20.62 mL | 41.25 mL |
| 2.5 mM | 0.82 mL | 4.12 mL | 8.25 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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产品说明书 for DIPPA hydrochloride
参考文献 for DIPPA hydrochloride
参考文献是支持产品生物活性的出版物。
Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547 PMID: 8201586
Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490 PMID: 7799399
If you know of a relevant reference for DIPPA hydrochloride, please let us know.
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关键词: DIPPA hydrochloride, DIPPA hydrochloride supplier, Selective, irreversible, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP2, Kappa, Opioid, 0794, Tocris Bioscience
2 篇 DIPPA hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DIPPA hydrochloride 的部分引用包括：
Carr and Lucki (2010) Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl) 210 295 PMID: 20369354
Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141
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