κ Opioid Receptors
The κ opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of G-protein-coupled receptors that also includes μ, δ and NOP receptors. Three variants of the receptor (designated κ1, κ2, and κ3) have been characterized.
κ Opioid Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 0699 | BRL 52537 hydrochloride |
| Potent and selective κ agonist | |
| 3195 | Dynorphin A |
| Endogenous κ agonist | |
| 1483 | GR 89696 fumarate |
| Subtype-selective κ agonist | |
| 7541 | Helianorphin-19 |
| Potent and selective G protein-biased κ opioid receptor (KOR) agonist | |
| 0778 | ICI 199,441 hydrochloride |
| Potent κ agonist | |
| 0822 | ICI 204,448 hydrochloride |
| κ agonist, acts peripherally | |
| 0471 | (+)-U-50488 hydrochloride |
| Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495) | |
| 0495 | (±)-U-50488 hydrochloride |
| Selective κ agonist | |
| 0496 | (-)-U-50488 hydrochloride |
| Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495) | |
κ Opioid Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 0794 | DIPPA hydrochloride |
| Selective and irreversible κ antagonist | |
| 4866 | ML 190 |
| Selective κ opioid receptor antagonist | |
Other |
|
| Cat. No. | Product Name / Activity |
| 5611 | Salvinorin B |
| Activates the κ-opioid DREADD (KORD) | |
The κ opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of G-protein-coupled receptors that also includes μ, δ and NOP receptors. Three variants of the receptor (designated κ1, κ2, and κ3) have been characterized. However only one cDNA clone has been identified, hence these receptor subtypes are likely to arise from interaction of one κ-opioid receptor protein with other membrane associated proteins.
κ Opioid receptors are located predominantly in the cerebral cortex, nucleus accumbens, claustrum and hypothalamus and have been implicated in the regulation of nociception, diuresis, feeding and neuroendocrine secretions. Dynorphins A and B and α-neoendorphin appear to be the endogenous ligands. The human gene encoding the κ opioid receptor has been localized to chromosome 8 (8q11.2).
External sources of pharmacological information for κ Opioid Receptors :
Literature for κ Opioid Receptors
Tocris offers the following scientific literature for κ Opioid Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
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Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
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