主页 / 药理学 / Transporters / Neurotransmitter Transporters / Nucleoside Transporters / Nucleoside Transporter Inhibitors / Dipyridamole

Dipyridamole

Cat. No. 0691 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Adenosine transport inhibitor
化学名： 2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Dipyridamole

Dipyridamole is a coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50 = 144.8 nM and Ki = 8.18 nM for ENT1).

化合物库 for Dipyridamole

Dipyridamole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Dipyridamole

分子量 504.63
公式 C24H40N8O4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 58-32-2
PubChem ID 3108
InChI Key IZEKFCXSFNUWAM-UHFFFAOYSA-N
Smiles OCCN(CCO)C1=NC(N2CCCCC2)=C2N=C(N=C(N3CCCCC3)C2=N1)N(CCO)CCO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dipyridamole

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100
ethanol 10

制备储备液 for Dipyridamole

以下数据基于产品分子量 504.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for Dipyridamole

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Dipyridamole

参考文献是支持产品生物活性的出版物。

Fujishige et al (1999) Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J.Biol.Chem. 274 18438 PMID: 10373451

Meester et al (1998) Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig. Br.J.Pharmacol. 124 729 PMID: 9690865

Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991 PMID: 9671792

Lin and Buolamwini et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949

If you know of a relevant reference for Dipyridamole, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Nucleoside Transporter Inhibitors

关键词: Dipyridamole, Dipyridamole supplier, adenosines, transport, inhibitors, inhibits, PDE5, 6, 10, 8, 11, ENT1, Uptake, Purine, Transporters, Pyrimidine, Equilibrative, Nucleoside, Monoamine, Neurotransmitter, Phosphodiesterases, vasodilator, 0691, Tocris Bioscience

3 篇 Dipyridamole 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dipyridamole 的部分引用包括：

Davidson et al (2016) Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass PLoS One 11 e0158981 PMID: 27384524

Nguyen et al (2015) Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism. Pharmacol Res Perspect 3 e00189 PMID: 27022463

Cunha et al (2015) Creatine, similarly to KA, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation. Sci Rep 11 215 PMID: 25702084

您是否知道使用了 Tocris Dipyridamole 的优秀论文？ 请告知我们.

Dipyridamole 的评论

目前没有该产品的评论。 Be the first to review Dipyridamole and earn rewards!

Have you used Dipyridamole?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review