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Submit Review(±)-ADX 71743
说明： Negative allosteric modulator of mGlu7 receptors; brain penetrant
化学名： 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone
纯度： ≥98% (HPLC)
生物活性 for (±)-ADX 71743
(±)-ADX 71743 is a negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.
化合物库 for (±)-ADX 71743
(±)-ADX 71743 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for (±)-ADX 71743
| 分子量 | 269.34 |
| 公式 | C17H19NO2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1431641-29-0 |
| PubChem ID | 53391766 |
| InChI Key | CPKZCQHJDFSOJT-UHFFFAOYSA-N |
| Smiles | CC(C=C1C)=CC=C1C(CC2=C3N=C(CC)O2)CC3=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (±)-ADX 71743
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.93 | 100 | |
| ethanol | 26.93 | 100 |
制备储备液 for (±)-ADX 71743
以下数据基于产品分子量 269.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.56 mL | 37.13 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.43 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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产品说明书 for (±)-ADX 71743
参考文献 for (±)-ADX 71743
参考文献是支持产品生物活性的出版物。
Klar et al (2015) Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 35 7600 PMID: 25972184
Tassin et al (2016) Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network. Front Neural Circuits 10 31 PMID: 27199672
If you know of a relevant reference for (±)-ADX 71743, please let us know.
关键词: (±)-ADX 71743, (±)-ADX 71743 supplier, (±)-ADX, 71743, potent, negative, allosteric, modulators, NAMs, mGlu7, receptors, metabotropic, glutamate, epilepsy, 1431641-29-0, Glutamate, (Metabotropic), Group, III, Receptors, 5715, Tocris Bioscience
1 篇 (±)-ADX 71743 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (±)-ADX 71743 的部分引用包括：
Harold D et al (2022) Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions. Mol Biol Cell 33 ar66 PMID: 35511883
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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