(±)-AMG 487

Name: (±)-AMG 487
Brand: Tocris Bioscience
SKU: 4487
Rating: 4 (1 reviews)

Cat. No. 4487 5 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： CXCR3 antagonist; inhibits cell migration and metastasis

化学名： N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide

纯度： ≥98% (HPLC)

说明书

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (±)-AMG 487

(±)-AMG 487 is an antagonist of CXCR3; inhibits binding of ¹²⁵I-IP-10 and ¹²⁵I-ITAC to CXCR3 (IC₅₀ values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC₅₀ values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.

This product is racemic.

化合物库 for (±)-AMG 487

(±)-AMG 487 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for (±)-AMG 487

分子量	603.59
公式	C₃₂H₂₈F₃N₅O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	947536-03-0
PubChem ID	10282265
InChI Key	WQTKNBPCJKRYPA-UHFFFAOYSA-N
Smiles	CCOC(C=C3)=CC=C3N2C(C1=CC=CN=C1N=C2C(N(CC4=CC=CN=C4)C(CC5=CC=C(OC(F)(F)F)C=C5)=O)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (±)-AMG 487

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	60.36	100

制备储备液 for (±)-AMG 487

以下数据基于产品分子量 603.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.28 mL	16.57 mL
5 mM	0.33 mL	1.66 mL	3.31 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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产品说明书 for (±)-AMG 487

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (±)-AMG 487

参考文献是支持产品生物活性的出版物。

Johnson et al (2007) Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg.Med.Chem.Lett. 17 3339 PMID: 17448658

Walser et al (2006) Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res. 66 7701 PMID: 16885372

Cambien et al (2009) Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. Br.J.Cancer 100 1755 PMID: 19436305

If you know of a relevant reference for (±)-AMG 487, please let us know.

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关键词: (±)-AMG 487, (±)-AMG 487 supplier, CXCR3, chemokine, receptors, antagonists, inhibitors, inhibits, cell, migration, metastasis, ±-AMG487, ±-AMG_487, Chemokine, CXC, Receptors, 4487, Tocris Bioscience

5 篇 (±)-AMG 487 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (±)-AMG 487 的部分引用包括：

Gordón-Alonso et al (2017) Galectin-3 captures IF.-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration. Nat Commun 8 793 PMID: 28986561

Hitoo et al (2021) Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis. Elife 10 PMID: 33720008

Karsten et al (2019) Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. Elife 8 PMID: 31631836

Tsunaki et al (2020) Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs. Nat Commun 11 1494 PMID: 32198421

Guo et al (2018) Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration. Stem Cell Res Ther. 9 281 PMID: 30359318

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(±)-AMG 487 的评论

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AMG 487 reduces the symptoms and inflammation in interstitial cystitis..

By Udai Singh on 01/04/2018

分析类型： In Vivo

种属： Mouse

I used this product to reduce the activated CXCR3+ T cells in mouse with chronic interstitial cystitis.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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