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Submit ReviewDL-AP5 Sodium salt
说明： Potent and selective NMDA antagonist; sodium salt of DL-AP5
化学名： DL-2-Amino-5-phosphonopentanoic acid sodium salt
纯度： ≥98% (HPLC)
生物活性 for DL-AP5 Sodium salt
DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.
DL mixture, D-isomer and L-isomer also available.
技术数据 for DL-AP5 Sodium salt
| 分子量 | 219.11 |
| 公式 | C5H11NNaO5P |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1303993-72-7 |
| PubChem ID | 52974251 |
| InChI Key | KWRCYAPNGUCHOE-UHFFFAOYSA-M |
| Smiles | [Na+].NC(CCCP(O)([O-])=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DL-AP5 Sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 21.91 | 100 |
制备储备液 for DL-AP5 Sodium salt
以下数据基于产品分子量 219.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.56 mL | 22.82 mL | 45.64 mL |
| 5 mM | 0.91 mL | 4.56 mL | 9.13 mL |
| 10 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.91 mL |
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产品说明书 for DL-AP5 Sodium salt
参考文献 for DL-AP5 Sodium salt
参考文献是支持产品生物活性的出版物。
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378 PMID: 6145492
If you know of a relevant reference for DL-AP5 Sodium salt, please let us know.
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关键词: DL-AP5 Sodium salt, DL-AP5 Sodium salt supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, DLAP5, AP5, NMDA, 3693, Tocris Bioscience
28 篇 DL-AP5 Sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DL-AP5 Sodium salt 的部分引用包括：
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Meng-Jung et al (2020) Electrical Imaging of Light-Induced Signals Across and Within Retinal Layers. Front Neurosci 14 563964 PMID: 33328846
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Mauro et al (2019) Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron 101 246-259.e6 PMID: 30522820
Thomsen et al (2016) Fixed single-cell transcriptomic characterization of human radial glial diversity. Sci Rep 13 87 PMID: 26524239
Pan et al (2016) Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice. PLoS One 6 28137 PMID: 27319800
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Zhao et al (2018) Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience 6 138 PMID: 30240608
Athilingam et al (2017) Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife 6 PMID: 29206101
Maschi and Klyachko (2017) Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses. Neuron 94 65 PMID: 28343869
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Purinergic Signal 10 e0131430 PMID: 26102354
Allan E et al (2016) Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice. Endocrinology 157 3621-30 PMID: 27501185
Xinhuai et al (2021) Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron. Elife 10 PMID: 33464205
Gerald W et al (2021) Protocol for detecting plastic changes in defined neuronal populations in neuropathic mice. STAR Protoc 2 100698 PMID: 34382022
Sophie et al (2021) Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption. iScience 24 103122 PMID: 34622169
Raul et al (2021) Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. Elife 10 PMID: 34787081
Yalun et al (2021) Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN. Elife 10 PMID: 34250900
Stephan A et al (2021) Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic 22 454-470 PMID: 34564930
Marla B et al (2021) Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility. Elife 10 PMID: 34913435
Richard A et al (2021) Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles. Neuron 109 938-946.e5 PMID: 33508244
Darío et al (2018) Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses. Elife 7 PMID: 30320552
Cazares et al (2016) Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn. J Neurosci 36 11208 PMID: 27807164
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Works as expected..
By
Anonymous on 06/01/2020
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Paraventricular nucleus of hypothalamus
DL-AP5 (40 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.
NMDA glutamate site antagonist.
By
Syed Ali on 01/04/2018
分析类型： Ex Vivo
种属： Mouse
This small molecule was used as NMDA glutamate site antagonist in ex-vivo patch clamp electrophysiology to investigate neuronal excitability.
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