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(±)-Eriodictyol

Cat. No. 7199 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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7199 has been discontinued.

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说明： Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
化学名： 2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for (±)-Eriodictyol

(±)-Eriodictyol is a potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.

技术数据 for (±)-Eriodictyol

分子量 288.26
公式 C15H12O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 4049-38-1
PubChem ID 11095
InChI Key SBHXYTNGIZCORC-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(CC(C3=CC(O)=C(C=C3)O)OC2=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (±)-Eriodictyol

分析证书/产品说明书
化学品安全技术说明书

参考文献 for (±)-Eriodictyol

参考文献是支持产品生物活性的出版物。

Smith and Smith et al (2020) Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed

Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598

Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376

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