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(±)-Eriodictyol

Cat. No. 7199 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
化学名： 2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (±)-Eriodictyol

(±)-Eriodictyol is a potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.

技术数据 for (±)-Eriodictyol

分子量 288.26
公式 C15H12O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 4049-38-1
PubChem ID 11095
InChI Key SBHXYTNGIZCORC-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(CC(C3=CC(O)=C(C=C3)O)OC2=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (±)-Eriodictyol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.83 100
ethanol 14.41 50

制备储备液 for (±)-Eriodictyol

以下数据基于产品分子量 288.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.35 mL 34.69 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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产品说明书 for (±)-Eriodictyol

分析证书/产品说明书
化学品安全技术说明书

参考文献 for (±)-Eriodictyol

参考文献是支持产品生物活性的出版物。

Smith and Smith et al (2020) Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed

Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598

Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376

If you know of a relevant reference for (±)-Eriodictyol, please let us know.

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关键词: (±)-Eriodictyol, (±)-Eriodictyol supplier, Transient, receptor, potential, vanilloid, 1, TRPV1, potent, antagonist, antagonists, antagonism, antioxidant, ACE2, ligand, SARS-CoV-2, COVID-19, Nrf2, signaling, activators, activator, activates, TRPV, 7199, Tocris Bioscience

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