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Submit Review(±)-McN 5652
说明： Potent, orally active 5-HT uptake inhibitor; also inhibits noradrenalin and dopamine uptake in vitro
别名： McN 5652-Z
化学名： (6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)phenyl]-pyrrolo[2,1-a]isoquinoline
纯度： ≥98% (HPLC)
生物活性 for (±)-McN 5652
(±)-McN 5652 is a potent, high affinity serotonin re-uptake inhibitor; selective in vivo. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer.
技术数据 for (±)-McN 5652
| 分子量 | 295.44 |
| 公式 | C19H21NS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 96795-89-0 |
| PubChem ID | 6336338 |
| InChI Key | YVKDUIAAPBKHMJ-MOPGFXCFSA-N |
| Smiles | [H][C@]23C1=CC=CC=C1[C@@H]([C@]4=CC=C(SC)C=C4)CN2CCC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (±)-McN 5652
参考文献 for (±)-McN 5652
参考文献是支持产品生物活性的出版物。
Shank et al (1988) McN-5652: a highly potent inhibitor of serotonin uptake. J.Pharmacol.Exp.Ther. 247 1032 PMID: 2905001
Maryanoff et al (1990) Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J.Med.Chem. 33 2793 PMID: 2213832
Smith et al (1991) Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats. Eur.J.Pharmacol. 196 85 PMID: 1831423
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关键词: (±)-McN 5652, (±)-McN 5652 supplier, Potent, orally, active, 5-HT, reuptake, inhibits, inhibitors, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, (±)-McN5652, McN5652Z, McN, 5652-Z, Adrenergic, Dopamine, 2148, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.