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(±)-ML 209

Cat. No. 5987 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： RORγt inverse agonist; suppresses Th17 cell differentiation
化学名： 3-(1,3-Benzodioxol-5-yl)-1-(cis-3,5-dimethyl-1-piperidinyl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (±)-ML 209

(±)-ML 209 is a RORγt inverse agonist (IC50 = 460 nM). Suppresses Th17 cell differentiation and IL17A expression in vitro. Does not suppress transcription of RORα. Minimal activity displayed on ERα, LXRα and thyroid hormone receptors (IC50 values >4.4 μM).

化合物库 for (±)-ML 209

(±)-ML 209 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (±)-ML 209

分子量 441.52
公式 C25H31NO6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1334526-14-5
PubChem ID 53385590
InChI Key YEKVAIMYYCZDLI-MCPYQZEQSA-N
Smiles COC1=CC(OC)=C(C(O)=C1)C(C2=CC=C3OCOC3=C2)CC(N4C[C@@H](C[C@@H](C4)C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (±)-ML 209

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.15 100

制备储备液 for (±)-ML 209

以下数据基于产品分子量 441.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.32 mL 22.65 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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参考文献 for (±)-ML 209

参考文献是支持产品生物活性的出版物。

Huang et al (2010) Identification of Potent and Selective RORγ Antagonists. Probe Reports from the NIH Molecular Libraries Program PMID: 23658948

Huang et al (2015) DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature 528 517 PMID: 26675721

Kojetin et al (2014) REV-ERB and ROR nuclear receptors as drug targets. Nat.Rev.Drug Discov. 13 197 PMID: 24577401

Wang et al (2014) Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors. Bioorg.Med.Chem. 22 692 PMID: 24388993

If you know of a relevant reference for (±)-ML 209, please let us know.

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关键词: (±)-ML 209, (±)-ML 209 supplier, RORγt, inverse, agonists, agonism, Th17, cell, differentiation, t, helper, cells, inhibitor, inhibits, MS, multiple, sclerosis, Retinoic, Acid-related, Orphan, Receptors, 5987, Tocris Bioscience

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