(±)-PPCC oxalate

Cat. No. 3870 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective sigma (σ) agonist (σ₁> σ₂)

化学名： (1R,2S)-rel-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester oxalate

纯度： ≥99% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (±)-PPCC oxalate

(±)-PPCC oxalate is a selective sigma (σ) receptor ligand. Displays high affinity for σ₁; also binds at σ₂ sites (K_i = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.

化合物库 for (±)-PPCC oxalate

(±)-PPCC oxalate is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for (±)-PPCC oxalate

分子量	469.53
公式	C₂₄H₂₉NO₃.C₂H₂O₄
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1781628-91-8
PubChem ID	90488889
InChI Key	IGJDSEGFEVKASG-KLELIYFTSA-N
Smiles	CC(C=C3)=CC=C3[C@@]1(C(OC)=O)C[C@@H]1CN2CCC(C4=CC=CC=C4)(O)CC2.CC(C=C7)=CC=C7[C@]5([C@](OC)=O)C[C@H]5CN6CCC(C8=CC=CC=C8)(O)CC6.O=C(O)C(O)=O.O=C(O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (±)-PPCC oxalate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	46.95	100
	ethanol	4.7	10

制备储备液 for (±)-PPCC oxalate

以下数据基于产品分子量 469.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.65 mL	21.3 mL
5 mM	0.43 mL	2.13 mL	4.26 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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产品说明书 for (±)-PPCC oxalate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (±)-PPCC oxalate

参考文献是支持产品生物活性的出版物。

Prezzavento et al (2007) Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 50 951 PMID: 17328523

Prezzavento et al (2008) A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 82 549 PMID: 18261749

Antonini et al (2009) Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J.Neurochem. 109 744 PMID: 19245662

If you know of a relevant reference for (±)-PPCC oxalate, please let us know.

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关键词: (±)-PPCC oxalate, (±)-PPCC oxalate supplier, selective, sigma, receptor, agonists, ligand, sigma2, sigma1, Sigma1, Receptors, 3870, Tocris Bioscience