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说明： High affinity and selective CB1 antagonist
化学名： 3-(4-Chlorophenyl)-N-[(4-Chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide
纯度： ≥98% (HPLC)
生物活性 for (±)-SLV 319
(±)-SLV 319 is a high affinity and selective CB1 receptor antagonist (Ki = 7.8 nM). Exhibits 1000-fold selectivity for CB1 over CB2 receptors. Inhibits CP 55,940-induced hypotension and WIN 55,212-2-induced hypothermia in vivo. Orally active.
技术数据 for (±)-SLV 319
| 分子量 | 487.4 |
| 公式 | C23H20Cl2N4O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 362519-49-1 |
| PubChem ID | 11179267 |
| InChI Key | AXJQVVLKUYCICH-UHFFFAOYSA-N |
| Smiles | ClC(C=C4)=CC=C4C1=NN(/C(NS(C3=CC=C(Cl)C=C3)(=O)=O)=N\C)CC1C2=CC=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (±)-SLV 319
参考文献 for (±)-SLV 319
参考文献是支持产品生物活性的出版物。
Lange et al (2004) Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists. J.Med.Chem. 47 627 PMID: 14736243
Lange et al (2005) Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorg.Med.Chem.Lett. 15 4794 PMID: 16140010
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关键词: (±)-SLV 319, (±)-SLV 319 supplier, (±)-SLV319, SLV, 319, SLV319, potent, selective, CB1, antagonists, cannabinoids, receptors, Receptors, 4605, Tocris Bioscience
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