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Submit ReviewDMCM hydrochloride
说明： Benzodiazepine inverse agonist
化学名： 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
纯度： ≥98% (HPLC)
生物活性 for DMCM hydrochloride
DMCM hydrochloride is a benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
化合物库 for DMCM hydrochloride
DMCM hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for DMCM hydrochloride
| 分子量 | 350.8 |
| 公式 | C17H18N2O4.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1215833-62-7 |
| PubChem ID | 45261899 |
| InChI Key | FHCRBVQGMZUJKY-UHFFFAOYSA-N |
| Smiles | CCC1=C(C(OC)=O)N=CC3=C1C2=CC(OC)=C(OC)C=C2N3.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DMCM hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 31.43 | 100 | |
| DMSO | 7.02 | 20 |
制备储备液 for DMCM hydrochloride
以下数据基于产品分子量 350.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.25 mL | 28.51 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.7 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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产品说明书 for DMCM hydrochloride
参考文献 for DMCM hydrochloride
参考文献是支持产品生物活性的出版物。
Petersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117 PMID: 6317396
Conto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417 PMID: 16297441
Sieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180 PMID: 11205417
If you know of a relevant reference for DMCM hydrochloride, please let us know.
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关键词: DMCM hydrochloride, DMCM hydrochloride supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, 3083, Tocris Bioscience
3 篇 DMCM hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DMCM hydrochloride 的部分引用包括：
Alia et al (2016) Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice Scientific Reports 6 37823 PMID: 27897203
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Virol 34 10219 PMID: 25080584
Nguyen et al (2013) GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site. J Neurosci 1527 131 PMID: 23835499
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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