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Submit ReviewDMH2
说明： Type I BMP receptor inhibitor
化学名： 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
纯度： ≥98% (HPLC)
生物活性 for DMH2
DMH2 is a type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
技术数据 for DMH2
| 分子量 | 451.52 |
| 公式 | C27H25N5O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1206711-14-9 |
| PubChem ID | 50997748 |
| InChI Key | DXLXRNZCYAYUED-UHFFFAOYSA-N |
| Smiles | C(C=N2)(C3=CC=C(OCCN4CCOCC4)C=C3)=CN1C2=C(C5=CC=NC6=C5C=CC=C6)C=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DMH2
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 2eq.HCl | 22.58 | 50 | |
| DMSO | 9.03 | 20 温和加热 |
制备储备液 for DMH2
以下数据基于产品分子量 451.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.43 mL | 22.15 mL | 44.29 mL |
| 2.5 mM | 0.89 mL | 4.43 mL | 8.86 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
| 25 mM | 0.09 mL | 0.44 mL | 0.89 mL |
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产品说明书 for DMH2
参考文献 for DMH2
参考文献是支持产品生物活性的出版物。
Tsugawa et al (2014) Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549 PMID: 25271257
If you know of a relevant reference for DMH2, please let us know.
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关键词: DMH2, DMH2 supplier, Type-1, BMP, bone, morphogenetic, protein, receptors, inhibitors, inhibits, ALK6, ALK2, ALK3, and, Other, Activin, Receptors, 5580, Tocris Bioscience
2 篇 DMH2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DMH2 的部分引用包括：
Gerard et al (2021) Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception. JCI Insight 6 PMID: 34464353
Stuart et al (2019) Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell 25 388 PMID: 31422912
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DMH2 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for DMH2
