TGF-β Signaling Pathway

mTOR ERK1/2 ROCK TGF-β
RI TGF-β
RII Ras Akt p70 S6K BMP
RI BMP
RII PI3K p38
MAPK PP2A

The transforming growth factor beta (TGF-β) signaling pathway regulates several cellular processes such as growth, division and proliferation alongside motility and adhesion. Disruption of this signaling pathway has been seen in human cancers such as gastric and colon cancer and advanced carcinoma.

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Signaling Pathway Key

Stimulates

Inhibits

Multistep Activation

Translocates

Kinase

Transcription Factor

Enzyme-linked Receptor

Phosphatase

Other Protein