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DMH4

Cat. No. 4471 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4471 has been discontinued.

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说明： Selective VEGFR-2 inhibitor
化学名： 6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyrimidine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for DMH4

DMH4 is a selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Displays antiangiogenic activity in vitro and in vivo.

技术数据 for DMH4

分子量 400.47
公式 C24H24N4O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 515880-75-8
PubChem ID 5329447
InChI Key SKZQZGSPYYHTQG-UHFFFAOYSA-N
Smiles C(C=N2)(C4=CC=C(OCCN5CCOCC5)C=C4)=CN1C2=C(C3=CC=CC=C3)C=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for DMH4

参考文献是支持产品生物活性的出版物。

Fraley et al (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg.Med.Chem.Lett. 12 3537 PMID: 12443771

Hao et al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245 PMID: 20020776

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关键词: DMH4, DMH4 supplier, VEGFR-2, inhibitors, inhibits, dorsomorphin, vascular, endothelial, growth, factor, receptor-2, KDR, VEGFR, 4471, Tocris Bioscience

1 篇 DMH4 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DMH4 的部分引用包括：

Lee et al (2017) Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest 127 457 PMID: 27991863

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for DMH4

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.