DMNPE-4 AM-caged-calcium

Cat. No. 5948 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Calcium cage; cell permeable

化学名： Bis(acetoxymethyl) 3,12-bis(2-(acetoxymethoxy)-2-oxoethyl)-5-(4,5-dimethoxy-2-nitrophenyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioate

纯度： ≥95% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DMNPE-4 AM-caged-calcium

DMNPE-4 AM-caged-calcium is a calcium cage. In the presence of calcium, the compound will chelate and cage calcium (K_d values are 48 and 19 nM at pH 7.2 and 7.4, respectively; K_d after uncaging = 2 mM). DMNPE-4 AM-caged-calcium is selective for Ca²⁺ over Mg²⁺ (K_d = 10 mM). Rapid and efficient calcium release occurs upon photolysis at 350 nm. It can also be used for two-photon uncaging. Extinction coefficient of 5120 M^-1 cm^-1, quantum yield 0.09. Cell permeable.

技术数据 for DMNPE-4 AM-caged-calcium

分子量	849.74
公式	C₃₄H₄₇N₃O₂₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2253744-58-8
PubChem ID	137919855
InChI Key	UUZFENOXYOBVDU-UHFFFAOYSA-N
Smiles	O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)CCOCCOC(CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(C=C1OC)=C(C=C1OC)[N+]([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DMNPE-4 AM-caged-calcium

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	84.97	100

制备储备液 for DMNPE-4 AM-caged-calcium

以下数据基于产品分子量 849.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.18 mL	5.88 mL	11.77 mL
5 mM	0.24 mL	1.18 mL	2.35 mL
10 mM	0.12 mL	0.59 mL	1.18 mL
50 mM	0.02 mL	0.12 mL	0.24 mL

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产品说明书 for DMNPE-4 AM-caged-calcium

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DMNPE-4 AM-caged-calcium

参考文献是支持产品生物活性的出版物。

Wang et al (2015) Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells Cell 163 1348 PMID: 26627734

Gordon et al (2008) Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature 456 745 PMID: 18971930

Ellis-Davies et al (2006) Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties. Cell Calcium 39 75 PMID: 16303177

If you know of a relevant reference for DMNPE-4 AM-caged-calcium, please let us know.

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关键词: DMNPE-4 AM-caged-calcium, DMNPE-4 AM-caged-calcium supplier, Caged, calcium, cell, permeable, rapid, photolysis, Second, Messenger, Compounds, Ca2+-Activated, Chloride, Channels, Non-selective, Cav, Potassium, General, Calcium, Signaling, Agents, 5948, Tocris Bioscience

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