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Submit ReviewDMNPE-4 AM-caged-calcium is a calcium cage. In the presence of calcium, the compound will chelate and cage calcium (Kd values are 48 and 19 nM at pH 7.2 and 7.4, respectively; Kd after uncaging = 2 mM). DMNPE-4 AM-caged-calcium is selective for Ca2+ over Mg2+ (Kd = 10 mM). Rapid and efficient calcium release occurs upon photolysis at 350 nm. It can also be used for two-photon uncaging. Extinction coefficient of 5120 M-1 cm-1, quantum yield 0.09. Cell permeable.
分子量 | 849.74 |
公式 | C34H47N3O22 |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 2253744-58-8 |
PubChem ID | 137919855 |
InChI Key | UUZFENOXYOBVDU-UHFFFAOYSA-N |
Smiles | O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)CCOCCOC(CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(C=C1OC)=C(C=C1OC)[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 84.97 | 100 |
以下数据基于产品分子量 849.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.18 mL | 5.88 mL | 11.77 mL |
5 mM | 0.24 mL | 1.18 mL | 2.35 mL |
10 mM | 0.12 mL | 0.59 mL | 1.18 mL |
50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
参考文献是支持产品生物活性的出版物。
Wang et al (2015) Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells Cell 163 1348 PMID: 26627734
Gordon et al (2008) Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature 456 745 PMID: 18971930
Ellis-Davies et al (2006) Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties. Cell Calcium 39 75 PMID: 16303177
If you know of a relevant reference for DMNPE-4 AM-caged-calcium, please let us know.
关键词: DMNPE-4 AM-caged-calcium, DMNPE-4 AM-caged-calcium supplier, Caged, calcium, cell, permeable, rapid, photolysis, Second, Messenger, Compounds, Ca2+-Activated, Chloride, Channels, Non-selective, Cav, Potassium, General, Calcium, Signaling, Agents, 5948, Tocris Bioscience
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