DMPQ dihydrochloride

Cat. No. 1222 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective inhibitor of PDGFRβ

化学名： 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DMPQ dihydrochloride

DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC₅₀ = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

技术数据 for DMPQ dihydrochloride

分子量	339.22
公式	C₁₆H₁₄N₂O₂.2HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	1123491-15-5
PubChem ID	45073427
InChI Key	YBBAOKYVJCNJIV-UHFFFAOYSA-N
Smiles	COC1=CC(OC)=C2C(N=CC(C3=CC=NC=C3)=C2)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DMPQ dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		100

制备储备液 for DMPQ dihydrochloride

以下数据基于产品分子量 339.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.74 mL	29.48 mL
5 mM	0.59 mL	2.95 mL	5.9 mL
10 mM	0.29 mL	1.47 mL	2.95 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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产品说明书 for DMPQ dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DMPQ dihydrochloride

参考文献是支持产品生物活性的出版物。

Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627 PMID: 8064792

If you know of a relevant reference for DMPQ dihydrochloride, please let us know.

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关键词: DMPQ dihydrochloride, DMPQ dihydrochloride supplier, Potent, selective, inhibitors, inhibits, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs, PDGFR, 1222, Tocris Bioscience

1 篇 DMPQ dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DMPQ dihydrochloride 的部分引用包括：

Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials 167 153 PMID: 29571051

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