DMPQ dihydrochloride

Discontinued Product

1222 has been discontinued.

View all PDGFR products.
说明: Potent, selective inhibitor of PDGFRβ
化学名: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
纯度: ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)

生物活性 for DMPQ dihydrochloride

DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

技术数据 for DMPQ dihydrochloride

分子量 339.22
公式 C16H14N2O2.2HCl
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1123491-15-5
PubChem ID 45073427
InChI Key YBBAOKYVJCNJIV-UHFFFAOYSA-N
Smiles COC1=CC(OC)=C2C(N=CC(C3=CC=NC=C3)=C2)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for DMPQ dihydrochloride

参考文献 for DMPQ dihydrochloride

参考文献是支持产品生物活性的出版物。

Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627 PMID: 8064792

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关键词: DMPQ dihydrochloride, DMPQ dihydrochloride supplier, Potent, selective, inhibitors, inhibits, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs, PDGFR, 1222, Tocris Bioscience

1 篇 DMPQ dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DMPQ dihydrochloride 的部分引用包括:

Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials 167 153 PMID: 29571051


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