DMXAA

Pricing Availability   Qty
说明: mSTING agonist; induces antitumor immunological responses
化学名: 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
纯度: ≥99% (HPLC)
说明书
引用文献 (2)
评论

生物活性 for DMXAA

DMXAA is a mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.

化合物库 for DMXAA

DMXAA is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for DMXAA

分子量 282.29
公式 C17H14O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 117570-53-3
PubChem ID 123964
InChI Key XGOYIMQSIKSOBS-UHFFFAOYSA-N
Smiles O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DMXAA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.65 20

制备储备液 for DMXAA

以下数据基于产品分子量 282.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 17.71 mL 88.56 mL 177.12 mL
1 mM 3.54 mL 17.71 mL 35.42 mL
2 mM 1.77 mL 8.86 mL 17.71 mL
10 mM 0.35 mL 1.77 mL 3.54 mL

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产品说明书 for DMXAA

分析证书/产品说明书
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关键词: DMXAA, DMXAA supplier, mouse, STING, antitumor, adaptive, immunity, tumors, immunology, microenvironment, antiviral, STING-Dependent, Signaling, Non-selective, Antivirals, 5601, Tocris Bioscience

2 篇 DMXAA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DMXAA 的部分引用包括:

Bryon D et al (2021) STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 12 41-58 PMID: 33548597

Umesh S et al (2020) Protocols for Experimental Sjögren's Syndrome. Curr Protoc Immunol 131 e114 PMID: 33252847


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