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Submit ReviewDMXAA
说明： mSTING agonist; induces antitumor immunological responses
化学名： 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
纯度： ≥99% (HPLC)
生物活性 for DMXAA
DMXAA is a mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.
化合物库 for DMXAA
DMXAA is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for DMXAA
| 分子量 | 282.29 |
| 公式 | C17H14O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 117570-53-3 |
| PubChem ID | 123964 |
| InChI Key | XGOYIMQSIKSOBS-UHFFFAOYSA-N |
| Smiles | O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DMXAA
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 5.65 | 20 |
制备储备液 for DMXAA
以下数据基于产品分子量 282.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 17.71 mL | 88.56 mL | 177.12 mL |
| 1 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 2 mM | 1.77 mL | 8.86 mL | 17.71 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
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产品说明书 for DMXAA
参考文献 for DMXAA
参考文献是支持产品生物活性的出版物。
Shirey et al (2011) The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J.Leukoc.Biol. 89 351 PMID: 21084628
Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018 PMID: 25959818
Phillips (1999) Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 58 303 PMID: 10423172
If you know of a relevant reference for DMXAA, please let us know.
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关键词: DMXAA, DMXAA supplier, mouse, STING, antitumor, adaptive, immunity, tumors, immunology, microenvironment, antiviral, STING-Dependent, Signaling, Non-selective, Antivirals, 5601, Tocris Bioscience
2 篇 DMXAA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DMXAA 的部分引用包括：
Umesh S et al (2020) Protocols for Experimental Sjögren's Syndrome. Curr Protoc Immunol 131 e114 PMID: 33252847
Bryon D et al (2021) STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 12 41-58 PMID: 33548597
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