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Submit ReviewDopamine hydrochloride
说明： Endogenous agonist at dopamine D1-5 receptors
化学名： 3,4-Dihydroxyphenethylamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Dopamine hydrochloride
Dopamine hydrochloride is an endogenous neurotransmitter that acts as an agonist at dopamine D1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis.
技术数据 for Dopamine hydrochloride
| 分子量 | 189.64 |
| 公式 | C8H11NO2.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 62-31-7 |
| PubChem ID | 65340 |
| InChI Key | CTENFNNZBMHDDG-UHFFFAOYSA-N |
| Smiles | NCCC1=CC(O)=C(O)C=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Dopamine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 18.96 | 100 | |
| DMSO | 18.96 | 100 |
制备储备液 for Dopamine hydrochloride
以下数据基于产品分子量 189.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.27 mL | 26.37 mL | 52.73 mL |
| 5 mM | 1.05 mL | 5.27 mL | 10.55 mL |
| 10 mM | 0.53 mL | 2.64 mL | 5.27 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.05 mL |
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产品说明书 for Dopamine hydrochloride
参考文献 for Dopamine hydrochloride
参考文献是支持产品生物活性的出版物。
Rivonello et al (2007) Novel insights into DA receptor pharmacology. Eur.J.Endocrinol. 156 S13 PMID: 17413183
Cools (2008) Role of DA in the motivational and cognitive control of behavior. Neuroscientist 14 381 PMID: 18660464
Fitzgerald and Dinan (2008) Prolactin and DA: what is the connection? A review article. J.Psychopharmacol. 22 S12
If you know of a relevant reference for Dopamine hydrochloride, please let us know.
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关键词: Dopamine hydrochloride, Dopamine hydrochloride supplier, Endogenous, agonists, dopamine, D1, receptors, Dopamine, D2, D3, Non-Selective, Receptors, D5, dopaminergic, TAAR1, and, Non-selective, Trace, Amine, 1, Receptor, 3548, Tocris Bioscience
21 篇 Dopamine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Dopamine hydrochloride 的部分引用包括：
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
KuÄka et al (2012) Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs. World J Gastroenterol 61 267 PMID: 22480423
Spencer T et al (2020) Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray. Elife 9 PMID: 32207681
Fang et al (2020) Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism. Oncotarget 11 4224-4242 PMID: 33245718
Mark D et al (2020) Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons. Neuron 106 277-290.e6 PMID: 32075716
Ning et al (2023) Autoregulation of GPCR signalling through the third intracellular loop. Nature 615 734-741 PMID: 36890236
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by DA. Elife 4 PMID: 26516682
Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768
Zheng et al (2014) Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Physiol Res 306 R138 PMID: 24305061
Guo (2017) DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. 16 1323 PMID: 28975698
Bénédicte et al (2015) Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab 22 646-57 PMID: 26278050
Zhang et al (2013) Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8 PMID: 23415661
Martin et al (2012) Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels. Learn Mem 19 294-9 PMID: 22723051
O'Keeffe et al (2009) DA-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A 106 8754 PMID: 19433789
Mou et al (2021) Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird. Nat Commun 12 2617 PMID: 33976169
Stefan et al (2021) New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Sci Rep 11 8288 PMID: 33859231
Sara R et al (2021) Bingeing on High-Fat Food Enhances Evoked Dopamine Release and Reduces Dopamine Uptake in the Nucleus Accumbens. Obesity (Silver Spring) 29 721-730 PMID: 33660412
Kira E et al (2022) Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep 40 111426 PMID: 36170823
Bryan L et al (2022) Agonist and antagonist TRUPATH assays for G protein-coupled receptors. STAR Protoc 3 101259 PMID: 35403009
Mark L et al (2022) History-dependent dopamine release increases cAMP levels in most basal amygdala glutamatergic neurons to control learning. Cell Rep 38 110297 PMID: 35081349
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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