Doxepin hydrochloride

Name: Doxepin hydrochloride
Brand: Tocris Bioscience
SKU: 0508

Cat. No. 0508 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0508 has been discontinued.

View all Histamine H<sub>1</sub> Receptors products.

说明： Highly potent H₁ antagonist. Also binds to H₄ receptor

化学名： 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Doxepin hydrochloride

Highly potent H₁ histamine receptor antagonist (K_d = 310 pM) and tricyclic antidepressant. Also binds to the H₄ histamine receptor (pK_i = 6.79).

This compound is a mixture of E/Z isomers (ratio: 85:15).

技术数据 for Doxepin hydrochloride

分子量	315.84
公式	C₁₉H₂₁NO.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	1229-29-4
PubChem ID	5281088
InChI Key	MHNSPTUQQIYJOT-CULRIWENSA-N
Smiles	Cl[H].CN(C)CC\C=C1\C2=C(COC3=C1C=CC=C3)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Doxepin hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Doxepin hydrochloride

参考文献是支持产品生物活性的出版物。

Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of dox. and other tricyclic antidepressants. Am.J.Psychiatry 140 1006 PMID: 6346907

Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427 PMID: 11179435

Tran et al (1981) [³H]Doxepin interactions with histamine H₁-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501 PMID: 7238574

Merck Index 12 3492

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关键词: Doxepin hydrochloride, Doxepin hydrochloride supplier, potent, H1, antagonists, binds, H4, Receptors, Histamine, histaminergic, 0508, Tocris Bioscience

1 篇 Doxepin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Doxepin hydrochloride 的部分引用包括：

Jones et al (2011) Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations. Br J Pharmacol 162 863 PMID: 20973775