DPNB-ABT 594

Name: DPNB-ABT 594
Brand: Tocris Bioscience
SKU: 6706

Cat. No. 6706 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6706 has been discontinued.

View all Caged Nicotinic Compounds products.

说明： Caged ABT 594 (Cat. No. 6576); suitable for one- or two-photon photolysis

化学名： 5-(((2R)-1-(1-(4,5-Bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-nitrophenyl)ethyl)azetidin-2-yl)methoxy)-2-chloropyridine

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for DPNB-ABT 594

DPNB-ABT 594 is a nitrobenzyl-caged ABT 594 (Cat. No. 6576), a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca²⁺ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination with appropriate two photon pulse laser at 710 nm for ~2 ms.

技术数据 for DPNB-ABT 594

分子量	672.16
公式	C₃₁H₄₆ClN₃O₁₁
储存	Store at -20°C
纯度	≥98% (HPLC)
Smiles	ClC1=NC=C(C=C1)OC[C@@H]2CCN2C(C)C3=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C3[N+]([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for DPNB-ABT 594

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DPNB-ABT 594

参考文献是支持产品生物活性的出版物。

Passlick et al (2018) Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J.Physiol. 596 5307 PMID: 30222192

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