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DPTN

Cat. No. 7628 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective A3 adenosine receptor antagonist
化学名： N-[4-(3,5-Dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-3-pyridinecarboxamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DPTN

DPTN is a potent and selective A3 adenosine receptor antagonist (Ki values are in the range 0.36 - 1.65 nM (hA3AR) and 1.6 - 8.53 nM (rA3AR)). Reduces intrapulmonary pressure when combined with Dexamethasone (Cat. No. 1126). Readily crosses the blood brain barrier in rats.

技术数据 for DPTN

分子量 459.39
公式 C22H18N4OS.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 325767-87-1
InChI Key GTWKWBXTCBUKTR-UHFFFAOYSA-N
Smiles CC1=CC(C2=C(C3=CC=NC=C3)SC(NC(C4=CN=CC=C4)=O)=N2)=CC(C)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DPTN

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.19 20 温和加热

制备储备液 for DPTN

以下数据基于产品分子量 459.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 10.88 mL 54.42 mL 108.84 mL
1 mM 2.18 mL 10.88 mL 21.77 mL
2 mM 1.09 mL 5.44 mL 10.88 mL
10 mM 0.22 mL 1.09 mL 2.18 mL

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参考文献 for DPTN

参考文献是支持产品生物活性的出版物。

Gao et al (2021) Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists. Purinergic Signal. 17 737 PMID: 34713378

Suresh et al (2022) Selective A3 adenosine receptor antagonist radioligand for human and rodent species. ACS Med.Chem.Lett. 13 623 PMID: 35450351

If you know of a relevant reference for DPTN, please let us know.

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关键词: DPTN, DPTN supplier, potent, selective, A3, adenosine, adrenoceptor, antagonist, anti-asthmatic, asthma, Adenosine, Receptors, 7628, Tocris Bioscience

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