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Submit ReviewDR 2313
说明： PARP-1 and PARP-2 inhibitor
化学名： 1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one
纯度： ≥99% (HPLC)
生物活性 for DR 2313
DR 2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.
技术数据 for DR 2313
| 分子量 | 182.24 |
| 公式 | C8H10N2OS |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 284028-90-6 |
| PubChem ID | 10219702 |
| InChI Key | HRYKZAKEAVZGJD-UHFFFAOYSA-N |
| Smiles | CC1=NC(=O)C2=C(N1)CCSC2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DR 2313
参考文献 for DR 2313
参考文献是支持产品生物活性的出版物。
Nakajima et al (2005) A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472 PMID: 15466246
Jagtap and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 4 421 PMID: 15864271
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关键词: DR 2313, DR 2313 supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, DR2313, Poly(ADP-ribose), 2496, Tocris Bioscience
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.