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Submit ReviewDREADD agonist 21 dihydrochloride
说明： Potent hM3Dq and hM4Di DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548)
别名： Compound 21 (water-soluble)
化学名： 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for DREADD agonist 21 dihydrochloride
DREADD agonist 21 dihydrochloride is a water soluble version of DREADD agonist 21 (Cat. No. 5548). Potent muscarinic DREADD agonist.
化合物库 for DREADD agonist 21 dihydrochloride
DREADD agonist 21 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for DREADD agonist 21 dihydrochloride
| 分子量 | 351.27 |
| 公式 | C17H18N4.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2250025-92-2 |
| PubChem ID | 134812837 |
| InChI Key | SETCOPAXYQJWKI-UHFFFAOYSA-N |
| Smiles | C1(N2CCNCC2)=NC(C=CC=C3)=C3NC4=C1C=CC=C4.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DREADD agonist 21 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 35.13 | 100 | |
| DMSO | 35.13 | 100 |
制备储备液 for DREADD agonist 21 dihydrochloride
以下数据基于产品分子量 351.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.23 mL | 28.47 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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产品说明书 for DREADD agonist 21 dihydrochloride
参考文献 for DREADD agonist 21 dihydrochloride
参考文献是支持产品生物活性的出版物。
Chen et al (2015) The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 18 476 PMID: 25587888
If you know of a relevant reference for DREADD agonist 21 dihydrochloride, please let us know.
关键词: DREADD agonist 21 dihydrochloride, DREADD agonist 21 dihydrochloride supplier, designer, receptors, drugs, DREADDs, hM3Dq, muscarinic, DREADD, ligands, chemogenetics, Compound, 21, (water-soluble), Non-selective, Muscarinics, 6422, Tocris Bioscience
5 篇 DREADD agonist 21 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DREADD agonist 21 dihydrochloride 的部分引用包括：
Xin et al (2023) Activation of basolateral amygdala to anterior cingulate cortex circuit alleviates MK-801 induced social and cognitive deficits of schizophrenia. Front Cell Neurosci 16 1070015 PMID: 36619672
Lung et al (2023) Medial and dorsal lateral septum involving social disruption stress-primed escalation in acid-induced writhes. Front Mol Neurosci 16 1158525 PMID: 37152428
Su-Jeong et al (2022) Neural activity in the mouse claustrum in a cross-modal sensory selection task. Neuron 110 486-501.e7 PMID: 34863367
Mark L et al (2020) Estimation of Current and Future Physiological States in Insular Cortex. Neuron 105 1094-1111.e10 PMID: 31955944
Nizar N et al (2020) Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe 27 614-628.e6 PMID: 32130954
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.
Allosteric GPCR Pharmacology Poster
G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.
GPCR Efficacy and Biased Agonism Poster
GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.