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dTRIM 24

Cat. No. 6607 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： TRIM24 Degrader (PROTAC®)
化学名： (2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for dTRIM 24

dTRIM 24 is a Degrader (PROTAC®) composed of the TRIM24 ligand IACS-9571 conjugated to a VHL ligand. Displays dose- and time-dependent degradation of TRIM24 in cells, with maximum degradation achieved at 5 μM. Degradation phenotypically mirrors genetic deletion of TRIM24. Demonstrates antiproliferative effects in MOLM-13 cells. Cell permeable.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

许可信息

Sold under license from Dana-Farber Cancer Institute

技术数据 for dTRIM 24

分子量 1113.3
公式 C55H68N8O13S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2170695-14-2
PubChem ID 131954388
InChI Key QUQTXFIMYFMULC-OGOZKGDESA-N
Smiles CCCOC1=CC=CC(OC2=C(C=C3N(C(N(C3=C2)C)=O)C)NS(=O)(C4=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)O)=O)=O)=O)=CC=C4)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for dTRIM 24

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.27 20
ethanol 22.27 20

制备储备液 for dTRIM 24

以下数据基于产品分子量 1113.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 4.49 mL 22.46 mL 44.91 mL
1 mM 0.9 mL 4.49 mL 8.98 mL
2 mM 0.45 mL 2.25 mL 4.49 mL
10 mM 0.09 mL 0.45 mL 0.9 mL

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参考文献 for dTRIM 24

参考文献是支持产品生物活性的出版物。

Gechijian et al (2018) Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat.Chem.Biol. 14 405 PMID: 29507391

If you know of a relevant reference for dTRIM 24, please let us know.

按标靶查看相关产品

关键词: dTRIM 24, dTRIM 24 supplier, dTRIM24, active, degraders, degrades, PROTAC, proteolysis, targeting, chimera, PROTACs, TRIM24, Tripartite, motif-containing, 24, transcriptional, intermediary, factor, 1alpha, TIF1α, targeted, protein, degradation, tpd, Other, Transcription, Factors, E3, Ligase, Degraders, 6607, Tocris Bioscience

1 篇 dTRIM 24 的引用文献

引用文献是使用了 Tocris 产品的出版物。 dTRIM 24 的部分引用包括：

Ma et al (2023) Engineered PROTAC-CID systems for mammalian inducible gene regulation J Am Chem Soc 145 1593 PMID: 36626587

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia