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Dynamin inhibitory peptide

Cat. No. 1774 13 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1774 has been discontinued.

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说明： Dynamin inhibitor
别名： P4
纯度： ≥95% (HPLC)
说明书
引用文献 (13)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Dynamin inhibitory peptide

Dynamin inhibitory peptide is a peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.

Cell-permeable version also available.

技术数据 for Dynamin inhibitory peptide

分子量 1121.26
公式 C47H80N18O14
序列 QVPSRPNRAP
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 251634-21-6
PubChem ID 90488708
InChI Key LHQOQXYEPUSHJL-LNIRUYPRSA-N
Smiles [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Dynamin inhibitory peptide

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参考文献 for Dynamin inhibitory peptide

参考文献是支持产品生物活性的出版物。

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920

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关键词: Dynamin inhibitory peptide, Dynamin inhibitory peptide supplier, Dynamin, inhibitors, inhibits, Mitosis, Epac, GTPases, P4, 1774, Tocris Bioscience

13 篇 Dynamin inhibitory peptide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dynamin inhibitory peptide 的部分引用包括：

Zhu et al (2012) Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents. J Neurophysiol 108 2581 PMID: 22914654

Chamma et al (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci 33 15488 PMID: 24068817

Glebov et al (2015) Clathrin-independent trafficking of AMPA receptors. J Biol Chem 35 4830 PMID: 25810514

Cuitino et al (2010) Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. PLoS One 30 8411 PMID: 20573888

Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951

Chiang et al (2014) Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles. Nat Commun 5 3356 PMID: 24561832

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. J Neurosci 10 e0131430 PMID: 26102354

Graziane et al (2009) DA D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Neurosci 284 8329 PMID: 19179335

Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952

Xia et al (2007) Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci 27 12221 PMID: 17989288

Dewerchin et al (2008) Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway. J Gen Virol 89 2731 PMID: 18931069

Grueter et al (2008) In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci 28 9261 PMID: 18784306

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