Dynamin inhibitory peptide

Discontinued Product

1774 has been discontinued.

View all Dynamin products.
说明: Dynamin inhibitor
别名: P4
纯度: ≥95% (HPLC)
说明书
引用文献 (13)
评论

生物活性 for Dynamin inhibitory peptide

Dynamin inhibitory peptide is a peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.

Cell-permeable version also available.

技术数据 for Dynamin inhibitory peptide

分子量 1121.26
公式 C47H80N18O14
序列 QVPSRPNRAP
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 251634-21-6
PubChem ID 90488708
InChI Key LHQOQXYEPUSHJL-LNIRUYPRSA-N
Smiles [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Dynamin inhibitory peptide

分析证书/产品说明书
选择另一批次:
化学品安全技术说明书目前不在网上提供。
请联系客户服务

参考文献 for Dynamin inhibitory peptide

参考文献是支持产品生物活性的出版物。

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920

按产品操作查看相关产品

查看全部 Dynamin Inhibitors

关键词: Dynamin inhibitory peptide, Dynamin inhibitory peptide supplier, Dynamin, inhibitors, inhibits, Mitosis, Epac, GTPases, P4, 1774, Tocris Bioscience

13 篇 Dynamin inhibitory peptide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dynamin inhibitory peptide 的部分引用包括:

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. J Neurosci 10 e0131430 PMID: 26102354

Graziane et al (2009) DA D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Neurosci 284 8329 PMID: 19179335

Zhu et al (2012) Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents. J Neurophysiol 108 2581 PMID: 22914654

Chamma et al (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci 33 15488 PMID: 24068817


Dynamin inhibitory peptide 的评论

目前没有该产品的评论。 Be the first to review Dynamin inhibitory peptide and earn rewards!

Have you used Dynamin inhibitory peptide?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review