Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDynapyrazole A
说明： Hedgehog signaling inhibitor; dynein inhibitor
化学名： 2-[1-(4-Chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxopyrazolo[1,5-a]quinazoline-3-carbonitrile
纯度： ≥98% (HPLC)
生物活性 for Dynapyrazole A
Dynapyrazole A is a dynein inhibitor. Inhibits dynein 1 and dynein 2-dependent microtubule gliding (IC50 values are 2.3 and 2.6 μM, respectively). Inhibits hedgehog signaling in vitro (IC50 = 1.9 μM). Displays reversible inhibition of retrograde and anterograde intraflagellar transport in Chlamydomonas; displays stronger inhibition of retrograde transport.
化合物库 for Dynapyrazole A
Dynapyrazole A is also offered as part of the Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Dynapyrazole A
| 分子量 | 486.7 |
| 公式 | C20H12ClIN4O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2226517-75-3 |
| PubChem ID | 136213044 |
| InChI Key | VABPBCMFKJDOHP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2(C3=NN4C(NC(C5=CC(I)=CC=C45)=O)=C3C#N)CC2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Dynapyrazole A
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 9.73 | 20 |
制备储备液 for Dynapyrazole A
以下数据基于产品分子量 486.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.27 mL | 51.37 mL | 102.73 mL |
| 1 mM | 2.05 mL | 10.27 mL | 20.55 mL |
| 2 mM | 1.03 mL | 5.14 mL | 10.27 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Dynapyrazole A
参考文献 for Dynapyrazole A
参考文献是支持产品生物活性的出版物。
Steinman et al (2017) Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife 6 e25174 PMID: 28524820
If you know of a relevant reference for Dynapyrazole A, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Dynapyrazole A, Dynapyrazole A supplier, dynein, inhibitors, inhibits, hedgehog, signaling, flagellar, transport, retrograde, anterograde, Hedgehog, Signaling, 6896, Tocris Bioscience
篇 Dynapyrazole A 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 Dynapyrazole A 的引用文献。 您是否知道使用了 Tocris Dynapyrazole A 的优秀论文？ 请告知我们.
Dynapyrazole A 的评论
目前没有该产品的评论。 Be the first to review Dynapyrazole A and earn rewards!
Have you used Dynapyrazole A?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.