主页 / 药理学 / Enzymes / GTPases / Dynamin / Dynamin Inhibitors / Dynole 34-2

Dynole 34-2

Cat. No. 4222 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Dynamin I inhibitor
化学名： 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Dynole 34-2

Dynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).

化合物库 for Dynole 34-2

Dynole 34-2 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Dynole 34-2

分子量 408.58
公式 C25H36N4O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1128165-88-7
PubChem ID 44157463
InChI Key MYIMRONQBLZJFI-DYTRJAOYSA-N
Smiles CN(C)CCCN2C1=CC=CC=C1C(/C=C(C(NCCCCCCCC)=O)\C#N)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dynole 34-2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.86 100
ethanol 20.43 50

制备储备液 for Dynole 34-2

以下数据基于产品分子量 408.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Dynole 34-2

参考文献是支持产品生物活性的出版物。

Hill et al (2009) Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 52 3762 PMID: 19459681

Hill et al (2010) Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 53 4094 PMID: 20426422

If you know of a relevant reference for Dynole 34-2, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Dynamin Inhibitors

关键词: Dynole 34-2, Dynole 34-2 supplier, dynamin, I, inhibitors, inhibits, gtpases, rme, receptor-mediated, endocytosis, Dynamin, 4222, Tocris Bioscience

4 篇 Dynole 34-2 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dynole 34-2 的部分引用包括：

Henri J et al (2014) Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP). PLoS One 9 e98619 PMID: 24932508

Alisha et al (2022) Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults. Elife 11 PMID: 36047587

Lasic (2017) Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements. Biochim Biophys Acta 1861 2293 PMID: 28669852

Han et al (2015) Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. Am J Physiol Cell Physiol 290 325 PMID: 25406314

您是否知道使用了 Tocris Dynole 34-2 的优秀论文？ 请告知我们.

Dynole 34-2 的评论

目前没有该产品的评论。 Be the first to review Dynole 34-2 and earn rewards!

Have you used Dynole 34-2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review