EB 47

Cat. No. 4140 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent PARP-1 inhibitor

化学名： 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for EB 47

EB 47 is a potent inhibitor of PARP-1 (IC₅₀ = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.

技术数据 for EB 47

分子量	610.45
公式	C₂₄H₂₇N₉O₆.2HCl
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	1190332-25-2
PubChem ID	90488915
InChI Key	VVMQSDIMNDTMII-MYXHFVDASA-N
Smiles	NC1=C2N=CN([C@@H]3O[C@@H]([C@@H](O)[C@H]3O)C(N4CCN(CC(NC5=C6CNC(C6=CC=C5)=O)=O)CC4)=O)C2=NC=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EB 47

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	3.05	5 温和加热
	DMSO	30.52	50

制备储备液 for EB 47

以下数据基于产品分子量 610.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.28 mL	16.38 mL	32.76 mL
2.5 mM	0.66 mL	3.28 mL	6.55 mL
5 mM	0.33 mL	1.64 mL	3.28 mL
25 mM	0.07 mL	0.33 mL	0.66 mL

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产品说明书 for EB 47

分析证书/产品说明书

化学品安全技术说明书

参考文献 for EB 47

参考文献是支持产品生物活性的出版物。

Jagtap et al (2004) The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). Bioorg.Med.Chem.Lett. 14 81 PMID: 14684303

Ferraris et al (2010) Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J.Med.Chem. 53 4561 PMID: 20364863

Gaymes et al (2009) Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 94 638 PMID: 19407318

If you know of a relevant reference for EB 47, please let us know.

按标靶查看相关产品

关键词: EB 47, EB 47 supplier, EB47, PARP-1, poly(ADP-ribose), polymerase-1, inhibitors, inhibits, PARP1, Poly(ADP-ribose), Polymerase, 4140, Tocris Bioscience

3 篇 EB 47 的引用文献

引用文献是使用了 Tocris 产品的出版物。 EB 47 的部分引用包括：

Rom et al (2016) PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier Journal of Neuroinflammation 13 254 PMID: 27677851

Rom et al (2015) Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. Front Microbiol 35 28 PMID: 25248836

Rom et al (2015) The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity. Dev Biol 6 878 PMID: 26379653

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