Edelfosine

Name: Edelfosine
Brand: Tocris Bioscience
SKU: 3022
Rating: 4 (1 reviews)

Cat. No. 3022 9 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

This product has been withdrawn from sale and is superseded by ET 18-OCH<sub>3</sub> (Cat. No. 7462)

说明： Selective PI-PLC inhibitor, also PAF receptor agonist

别名： ET-18-OCH₃

化学名： (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide

说明书

引用文献 (9)

生物活性技术数据说明书参考文献

生物活性 for Edelfosine

Edelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC₅₀= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.

技术数据 for Edelfosine

分子量	523.73
公式	C₂₇H₅₈NO₆P
储存	Store at -20°C
CAS Number	77286-66-9
PubChem ID	6918215
InChI Key	MHFRGQHAERHWKZ-HHHXNRCGSA-N
Smiles	CO[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Edelfosine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Edelfosine

参考文献是支持产品生物活性的出版物。

Powis et al (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52 2835 PMID: 1316230

Aoki et al (1995) A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 186 225 PMID: 7594622

Shimizu et al (2007) Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 571 138 PMID: 17628524

Wong et al (2007) Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 8 15 PMID: 17509155

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Phospholipase Inhibitors

关键词: Edelfosine, Edelfosine supplier, Selective, PI-PLC, inhibitors, inhibits, PAF, receptor, Phospholipases, C, Phosphoinositide-Specific, Esterases, Platelet-activating, Factor, Receptors, ET18OCH3, ET-18-OCH3, (PAF), Phospholipase, 3022, Tocris Bioscience