Eeyarestatin I

Cat. No. 3922 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent inhibitor of ER-associated protein degradation and translocation

化学名： 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

纯度： ≥98% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Eeyarestatin I

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquitinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. Also enhances adeno-associated viral transduction in multiple cells types.

技术数据 for Eeyarestatin I

分子量	630.44
公式	C₂₇H₂₅Cl₂N₇O₇
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	412960-54-4
PubChem ID	23947580
InChI Key	JTUXTPWYZXWOIB-LWWHHIEBSA-N
Smiles	O=C1N(C2=CC=C(Cl)C=C2)C(N(O)C(NC4=CC=C(Cl)C=C4)=O)C(C)(C)N1CC(N/N=C/C=C/C3=CC=C([N+]([O-])=O)O3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Eeyarestatin I

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	63.04	100

制备储备液 for Eeyarestatin I

以下数据基于产品分子量 630.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.93 mL	15.86 mL
5 mM	0.32 mL	1.59 mL	3.17 mL
10 mM	0.16 mL	0.79 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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产品说明书 for Eeyarestatin I

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Eeyarestatin I

参考文献是支持产品生物活性的出版物。

Wang et al (2008) Inhibition of p97-dependent protein degradation by eeyarestatin I. J.Biol.Chem. 283 7445 PMID: 18199748

Aletrari et al (2011) Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. PLoS One 6 e22713 PMID: 21799938

Wang et al (2008) ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc.Natl.Acad.Sci.USA 106 2200

Cross et al (2009) Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum. J.Cell Science 122 4393

Berry and Asokan et al (2016) Chemical modulation of endocytic sorting augments adeno-associated viral transduction. J.Biol.Chem. 291 939 PMID: 26527686

If you know of a relevant reference for Eeyarestatin I, please let us know.

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关键词: Eeyarestatin I, Eeyarestatin I supplier, endoplasmic, reticulum, ER, associated, protein, degradation, ERAD, translocation, inhibitors, inhibits, ER-stress, viral, transduction, enhancers, enhances, Other, stress/UPR, Translocation, Viral, Transduction, Enhancers, 3922, Tocris Bioscience