Efonidipine hydrochloride monoethanolate

Name: Efonidipine hydrochloride monoethanolate
Brand: Tocris Bioscience
SKU: 3733

Cat. No. 3733 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3733 has been discontinued.

View all Ca<sub>V</sub>1.x Channels (L-type) products.

说明： Ca_V1.x and Ca_V3.x blocker

化学名： 5-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid 2-[phenyl(phenylmethyl)amino]ethyl ester hydrochloride monoethanolate

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性

Selective blocker of L-type and T-type Ca²⁺ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R(-) and S(+)-enantiomers display different channel selectivity; S(+)-Efonidipine blocks L-type and T-type channels whereas R(-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.

技术数据

分子量	714.18
公式	C₃₄H₃₈N₃O₇P.HCl.C₂H₅OH
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	111011-76-8
PubChem ID	163838
InChI Key	IKBJGZQVVVXCEQ-UHFFFAOYSA-N
Smiles	CC1=C(P4(OCC(C)(C)CO4)=O)C(C3=CC([N+]([O-])=O)=CC=C3)C(C(OCCN(CC5=CC=CC=C5)C2=CC=CC=C2)=O)=C(C)N1.CCO.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Masumiya et al (1998) Inhibition of myocardial L- and T-type Ca²⁺ currents by efonidipine: possible mechanism for its chronotropic effect. Eur.J.Pharmacol. 349 351 PMID: 9671117

Furukawa et al (2004) Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca²⁺ channels. Br.J.Pharmacol. 143 1050 PMID: 15545287

Shin et al (2008) A selective T-type Ca²⁺ channel blocker R(-) efonidipine. Naunyn-Schmied.Arch.Pharmacol. 377 411

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关键词: Efonidipine hydrochloride monoethanolate, Efonidipine hydrochloride monoethanolate supplier, L-type, T-type, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, Cav1.x, Channels, Cav3.x, 3733, Tocris Bioscience

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