CaV3.x Channels (T-type)
CaV3.x channels (T-type) are low-voltage activated channels with low single channel conductance. These channels are found in cells with rhythmic firing patterns where repetitive firing of action potentials is required. For example, they contribute the pacemaker potential of sinoatrial node cells in the heart, and also to the spontaneous spiking of neurons in the thalamus.
CaV3.x Channel (T-type) Activators |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 6239 | SAK 3 |
| Potent CaV3.1 and 3.3 activator; orally bioavailable | |
CaV3.x Channel (T-type) Blockers |
|
| Cat. No. | Product Name / Activity |
| 6770 | ABT 639 |
| CaV3.2 and CaV3.1 channel blocker; orally bioavailable | |
| 4055 | L-Ascorbic acid |
| Selective CaV3.2 blocker | |
| 2198 | Mibefradil dihydrochloride |
| CaV3.x blocker | |
| 4507 | ML 218 hydrochloride |
| CaV3.x blocker | |
| 2268 | NNC 55-0396 dihydrochloride |
| Highly selective CaV3.x blocker | |
| 6367 | Z 944 |
| CaV3.x blocker | |
CaV3.x channels (T-type) are low-voltage activated channels with low single channel conductance. They are named T-type for their transient opening, resulting from their rapid and complete inactivation at positive membrane potentials. These channels are thought to consist only of a CaV3.x α1-subunit, with no auxiliary subunits.
Due to their properties and channel kinetics, CaV3.x channels are found in cells with rhythmic firing patterns where repetitive firing of action potentials is required. For example, they contribute the pacemaker potential of sinoatrial node cells in the heart, and also to the spontaneous spiking of neurons in the thalamus.
External sources of pharmacological information for CaV3.x Channels (T-type) :
Voltage-gated Calcium Channel Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| Cav3.1 | Human | CACNA1G | NM_018896 | Q9Y5T3 |
| Mouse | Cacna1g | NM_009783 | NP_033913 | |
| Rat | Cacna1g | NM_031601 | Q9JL92 | |
| Cav3.2 | Human | CACNA1H | NM_001005407 | O95180 |
| Mouse | Cacna1h | NM_021415 | O88427 | |
| Rat | Cacna1h | NM_153814 | Q9EQ60 | |
| Cav3.3 | Human | CACNA1I | NM_001003406 | Q9ULU9 |
| Mouse | Cacna1i | NM_001044308 | NP_001037773 | |
| Rat | Cacna1i | NM_020084 | Q9Z0Y8 |