Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewEggmanone
说明： Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
化学名： 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
纯度： ≥98% (HPLC)
生物活性 for Eggmanone
Eggmanone is a potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1.
技术数据 for Eggmanone
| 分子量 | 416.58 |
| 公式 | C20H20N2O2S3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 505068-32-6 |
| PubChem ID | 1158635 |
| InChI Key | XAKJIQPEGSCYIP-UHFFFAOYSA-N |
| Smiles | CC(CN1C(C2=C(N=C1SCC(C3=CC=CS3)=O)SC4=C2CCCC4)=O)=C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Eggmanone
参考文献 for Eggmanone
参考文献是支持产品生物活性的出版物。
Williams et al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43 PMID: 25818300
按产品操作查看相关产品
关键词: Eggmanone, Eggmanone supplier, Potent, selective, phosphodiesterases, PDE, 4, inhibitors, inhibits, hedgehog, signallling, Phosphodiesterases, Hedgehog, Signaling, 5695, Tocris Bioscience
1 篇 Eggmanone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Eggmanone 的部分引用包括：
Kan et al (2018) Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification. Bone 109 71 PMID: 28645539
Eggmanone 的评论
目前没有该产品的评论。 Be the first to review Eggmanone and earn rewards!
Have you used Eggmanone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image