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EHop 016

Cat. No. 6248 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Rac inhibitor
化学名： N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EHop 016

EHop 016 is a Rac inhibitor (IC50 = 1.1 μM). Exhibits some selectivity for Rac1 and Rac3 over Cdc42. Blocks the interaction of Rac with guanine nucleotide exchange factor Vav2 in breast cancer cell lines expressing high levels of Rac activity and inhibits activity of Rac downstream effector PAK1. Also inhibits mammary tumor growth and metastasis in mice.

化合物库 for EHop 016

EHop 016 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for EHop 016

分子量 430.55
公式 C25H30N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1380432-32-5
PubChem ID 51031035
InChI Key AFTZZRFCMOAFCR-UHFFFAOYSA-N
Smiles CCN1C2=CC=C(NC3=NC(NCCCN4CCOCC4)=NC=C3)C=C2C5=CC=CC=C51

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EHop 016

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 21.53 50

制备储备液 for EHop 016

以下数据基于产品分子量 430.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.65 mL 23.23 mL 46.45 mL
2.5 mM 0.93 mL 4.65 mL 9.29 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
25 mM 0.09 mL 0.46 mL 0.93 mL

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参考文献 for EHop 016

参考文献是支持产品生物活性的出版物。

Castillo-Pichardo et al (2014) The Rac inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model. Transl.Oncol. 7 546 PMID: 25389450

Montalvo-Ortiz et al (2012) Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J.Biol.Chem. 287 13228 PMID: 22383527

If you know of a relevant reference for EHop 016, please let us know.

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关键词: EHop 016, EHop 016 supplier, EHop016, Rac, inhibitors, inhibits, Vav2, GEFs, guanine, nucleotide, exchange, factors, Rac1, Rac3, Rho, 6248, Tocris Bioscience

1 篇 EHop 016 的引用文献

引用文献是使用了 Tocris 产品的出版物。 EHop 016 的部分引用包括：

Ginam et al (2021) β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep 11 21477 PMID: 34728663

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