EHT 1864

Name: EHT 1864
Brand: Tocris Bioscience
SKU: 3872
Rating: 3 (1 reviews)

Cat. No. 3872 32 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent Rac family inhibitor

化学名： 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (32)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for EHT 1864

EHT 1864 is an inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (K_D values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β-amyloid peptide production in vivo.

许可信息

Sold for research use only under license from ExonHit Therapeutics S.A.

化合物库 for EHT 1864

EHT 1864 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for EHT 1864

分子量	581.47
公式	C₂₅H₂₇F₃N₂O₄S.2HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	754240-09-0
PubChem ID	9938202
InChI Key	LSECOAJFCKFQJG-UHFFFAOYSA-N
Smiles	O=C1C=C(CN4CCOCC4)OC=C1OCCCCCSC3=CC=NC2=CC(C(F)(F)F)=CC=C23.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EHT 1864

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	11.63	20
	DMSO	43.61	75

制备储备液 for EHT 1864

以下数据基于产品分子量 581.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.75 mM	2.29 mL	11.47 mL	22.93 mL
3.75 mM	0.46 mL	2.29 mL	4.59 mL
7.5 mM	0.23 mL	1.15 mL	2.29 mL
37.5 mM	0.05 mL	0.23 mL	0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for EHT 1864

分析证书/产品说明书

化学品安全技术说明书

参考文献 for EHT 1864

参考文献是支持产品生物活性的出版物。

Desire et al (2005) RAC1 inhibition targets amyloid precursor protein processing by γ-secretase and decreases Aβ production in vitro and in vivo. J.Biol.Chem. 280 37516 PMID: 16150730

Shutes et al (2007) Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of rac family small GTPases. J.Biol.Chem. 282 35666 PMID: 17932039

Onesto et al (2008) Characterization of EHT1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol. 439 111 PMID: 18374160

If you know of a relevant reference for EHT 1864, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Rho GTPase Inhibitors

关键词: EHT 1864, EHT 1864 supplier, Rac-GEF, interaction, antioncogenic, G, Proteins, Small, transformation, Rac1, Rac1b, Rac2, Rac3, Ras, Tiam, inhibits, inhibitors, GTPases, EHT1864, Rho, 3872, Tocris Bioscience