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Submit ReviewEicosapentaenoic Acid
说明： Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation
化学名： (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic acid
纯度： ≥98%
生物活性 for Eicosapentaenoic Acid
Endogenous polyunsaturated fatty acid. Stimulates ERK1/2 and C/EBPβ phosphorylation, and induces demethylation of CpG island B in U937 leukemia cells. Attenuates proliferation of U9137 cells, and induces cell cycle arrest and apoptosis in pancreatic cells in vitro. Also inhibits leukotriene B4 synthesis in rats.
技术数据 for Eicosapentaenoic Acid
| 分子量 | 302.45 |
| 公式 | C20H30O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% |
| CAS Number | 10417-94-4 |
| PubChem ID | 446284 |
| InChI Key | JAZBEHYOTPTENJ-JLNKQSITSA-N |
| Smiles | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Eicosapentaenoic Acid
参考文献 for Eicosapentaenoic Acid
参考文献是支持产品生物活性的出版物。
Ceccarelli et al (2014) Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. PLoS One 9 e85025 PMID: 24454781
James et al (1993) Effect of dietary supplementation with n-9 eicosatrienoic acid on leukotriene B4 synthesis in rats: a novel approach to inhibition of eicosanoid synthesis. J.Exp.Med. 178 2261 PMID: 8245797
Lai et al (1996) Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro. Br.J.Cancer 74 1375 PMID: 8912532
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for Eicosapentaenoic Acid
