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Submit ReviewEMD 386088 hydrochloride
说明： Potent 5-HT6 agonist
化学名： 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride
纯度： ≥99% (HPLC)
生物活性 for EMD 386088 hydrochloride
EMD 386088 hydrochloride is a potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM).
化合物库 for EMD 386088 hydrochloride
EMD 386088 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for EMD 386088 hydrochloride
| 分子量 | 283.2 |
| 公式 | C14H15N2Cl.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1171123-46-8 |
| PubChem ID | 56972198 |
| InChI Key | WWSNDUWIZDYGIQ-UHFFFAOYSA-N |
| Smiles | Cl.CC1=C(C2=CC(Cl)=CC=C2N1)C1=CCNCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for EMD 386088 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 7.08 | 25 | |
| DMSO | 28.32 | 100 |
制备储备液 for EMD 386088 hydrochloride
以下数据基于产品分子量 283.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.53 mL | 17.66 mL | 35.31 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.53 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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产品说明书 for EMD 386088 hydrochloride
参考文献 for EMD 386088 hydrochloride
参考文献是支持产品生物活性的出版物。
Mattsson et al (2005) 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg.Med.Chem.Lett. 15 4230 PMID: 16055331
If you know of a relevant reference for EMD 386088 hydrochloride, please let us know.
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关键词: EMD 386088 hydrochloride, EMD 386088 hydrochloride supplier, Potent, 5-HT6, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, EMD386088, hydrochloride, 2382, Tocris Bioscience
3 篇 EMD 386088 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 EMD 386088 hydrochloride 的部分引用包括：
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552
Ly et al (2013) Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation. ACS Chem Neurosci 4 191 PMID: 23336058
Riccio et al (2011) Excess of serotonin affects neocortical pyramidal neuron migration. Transl Psychiatry 1 e47 PMID: 22833193
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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