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EMD 66684

Cat. No. 1849 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1849 has been discontinued.

View all Angiotensin AT<sub>1</sub> Receptors products.
说明： Potent and selective non-peptide AT1 antagonist
化学名： 2-Butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl-4-yl]methyl]-5H-imidazo[4,5-c]pyridine-5-acetamide hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for EMD 66684

EMD 66684 is a highly potent and very selective non-peptide angiotensin AT1 receptor antagonist (IC50 values are 0.7 and > 10000 nM for AT1 and AT2 receptors respectively). Potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC50 = 0.2 nM) and reduces blood pressure in hypertensive rats.

化合物库 for EMD 66684

EMD 66684 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for EMD 66684

分子量 547.05
公式 C28H30N8O2.HCl
储存 Desiccate at +4°C
纯度 ≥98% (HPLC)
CAS Number 1216884-39-7
PubChem ID 56972165
InChI Key YMFXGXGDHBXTPY-UHFFFAOYSA-N
Smiles Cl.CCCCC1=NC2=C(N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NN=NN1)C(=O)N(CC(=O)N(C)C)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for EMD 66684

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化学品安全技术说明书

参考文献 for EMD 66684

参考文献是支持产品生物活性的出版物。

Mederski et al (1994) Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J.Med.Chem. 37 1632 PMID: 8201597

Mederski et al (1995) 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor. Bioorg.Med.Chem.Lett. 5 2665

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关键词: EMD 66684, EMD 66684 supplier, Potent, selective, non-peptide, AT1, antagonists, Receptors, Angiotensin, EMD66684, 1849, Tocris Bioscience

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