Emetine dihydrochloride

Cat. No. 7342 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： RNA polymerase inhibitor; inhibits replication of a broad range of RNA and DNA viruses, including SARS-CoV-2 and Zika

化学名： (2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine dihydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Emetine dihydrochloride

Emetine is a RNA polymerase inhibitor. It inhibits SARS-CoV-2 replication (EC₅₀ = 460 nM) and in combination with Remdesivir (Cat. No.7226) synergistically inhibits the viral yield of SARS-CoV-2 by 64.9%. Emetine attenuates hCoV-OC43, hCoV-NL43, SARS-CoV, MERS-CoV, and MHV-A59 in vitro with EC₅₀ values in the low micromolar range. It also inhibits replication of a broad range of RNA and DNA viruses, including influenza, ebolavirus and HIV-1. Emetine potently inhibits ZIKV replication in vitro (IC₅₀ = 52.9 nm) and suppresses ZIKV viral load in vivo. Anti-inflammatory, antiviral, antimalarial, antibacterial and anti-amebic.

技术数据 for Emetine dihydrochloride

分子量	553.57
公式	C₂₉H₄₀N₂O₄.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	316-42-7
PubChem ID	3068143
InChI Key	JROGBPMEKVAPEH-GXGBFOEMSA-N
Smiles	[H][C@@]1(NCCC2=CC(OC)=C(C=C12)OC)C[C@H]3C[C@@]4(N(C[C@@H]3CC)CCC5=CC(OC)=C(C=C45)OC)[H].Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Emetine dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	55.36	100

制备储备液 for Emetine dihydrochloride

以下数据基于产品分子量 553.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.03 mL	18.06 mL
5 mM	0.36 mL	1.81 mL	3.61 mL
10 mM	0.18 mL	0.9 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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产品说明书 for Emetine dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Emetine dihydrochloride

参考文献是支持产品生物活性的出版物。

Yang et al (2018) Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 4 doi: 10.1038 PMID: 29872540

Choy (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 178 doi: 10.1016 PMID: 32251767

Bleasel et al (2020) Emetine, ipecac, ipecac alkaloids and analogues as potential antiviral agents for coronaviruses. Pharmaceuticals (Basel) 13 51 PMID: 32245264

Bleasel et al (2020) Emetine is not Ipecac: considerations for its use as treatment for SARS-CoV2. Pharmaceuticals (Basel) 13 428 PMID: 33261173

Killick et al (2020) Transcription-based drug repurposing for COVID-19. Virus Res. 290 198176 PMID: 32987033

If you know of a relevant reference for Emetine dihydrochloride, please let us know.

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