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EMI 48

Cat. No. 7424 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of EGFR mutants
化学名： 7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EMI 48

EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.

技术数据 for EMI 48

分子量 348.4
公式 C21H20N2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 34564-13-1
PubChem ID 15538560
InChI Key PTAGJQADNFQMGR-UHFFFAOYSA-N
Smiles CCN(C1=CC=C2C=C(C(OC2=C1)=O)C3=NC4=C(C=CC(C)=C4)O3)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EMI 48

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.97 20 温和加热

制备储备液 for EMI 48

以下数据基于产品分子量 348.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 14.35 mL 71.76 mL 143.51 mL
1 mM 2.87 mL 14.35 mL 28.7 mL
2 mM 1.44 mL 7.18 mL 14.35 mL
10 mM 0.29 mL 1.44 mL 2.87 mL

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参考文献 for EMI 48

参考文献是支持产品生物活性的出版物。

Saraon et al (2020) A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat.Chem.Biol. 16 577 PMID: 32094923

If you know of a relevant reference for EMI 48, please let us know.

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关键词: EMI 48, EMI 48 supplier, EMI48, EGFR, inhibitors, inhibits, degradation, mutant, endothelial, growth, factors, receptors, L858R, T970M, C797S, ex19del, 7424, Tocris Bioscience

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