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Submit ReviewEMI 48
说明： Inhibitor of EGFR mutants
化学名： 7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one
纯度： ≥98% (HPLC)
生物活性 for EMI 48
EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.
技术数据 for EMI 48
| 分子量 | 348.4 |
| 公式 | C21H20N2O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 34564-13-1 |
| PubChem ID | 15538560 |
| InChI Key | PTAGJQADNFQMGR-UHFFFAOYSA-N |
| Smiles | CCN(C1=CC=C2C=C(C(OC2=C1)=O)C3=NC4=C(C=CC(C)=C4)O3)CC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for EMI 48
参考文献 for EMI 48
参考文献是支持产品生物活性的出版物。
Saraon et al (2020) A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat.Chem.Biol. 16 577 PMID: 32094923
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关键词: EMI 48, EMI 48 supplier, EMI48, EGFR, inhibitors, inhibits, degradation, mutant, endothelial, growth, factors, receptors, L858R, T970M, C797S, ex19del, 7424, Tocris Bioscience
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