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Submit ReviewEndomorphin-1
Discontinued Product
1055 has been discontinued.
说明： Potent and selective μ agonist
纯度： ≥95% (HPLC)
生物活性 for Endomorphin-1
Endomorphin-1 is a endogenous peptide with an exceptionally high affinity (Ki = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).
技术数据 for Endomorphin-1
| 分子量 | 610.67 |
| 公式 | C34H38N6O5 |
| 序列 |
YPWF (Modification: Phe-4 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 189388-22-5 |
| PubChem ID | 5311080 |
| InChI Key | ZEXLJFNSKAHNFH-SYKYGTKKSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Endomorphin-1
参考文献 for Endomorphin-1
参考文献是支持产品生物活性的出版物。
Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962
Harrison et al (1998) Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19 749 PMID: 9622031
Kakizawa et al (1998) Parallel stimulations of in vitro and in situ [35S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 19 755 PMID: 9622032
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409
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关键词: Endomorphin-1, Endomorphin-1 supplier, Potent, selective, μ-opioid, mu-opioid, agonists, MOP, Receptors, OP3, Mu, Opioid, 1055, Tocris Bioscience
3 篇 Endomorphin-1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Endomorphin-1 的部分引用包括：
Hauser et al (2018) Pharmacogenomics of GPCR Drug Targets. Cell 172 41 PMID: 29249361
Garzón et al (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology 29 1091 PMID: 14997173
Dortch-Carnes and Russell (2007) Morphine-stimulated nitric oxide release in rabbit aqueous humor. Am J Physiol Endocrinol Metab 84 185 PMID: 17094965
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