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Submit ReviewEndomorphin-2
Discontinued Product
1056 has been discontinued.
说明： Potent and selective μ agonist
纯度： ≥95% (HPLC)
生物活性 for Endomorphin-2
Endomorphin-2 is a endogenous peptide with extremely high affinity and selectivity for μ-opioid receptors (with Ki values of 0.69, 9233 and 5240 nM for μ, δ and κ respectively).
技术数据 for Endomorphin-2
| 分子量 | 571.65 |
| 公式 | C32H37N5O5 |
| 序列 |
YPFF (Modifications: Phe-3 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 141801-26-5 |
| PubChem ID | 5311081 |
| InChI Key | XIJHWXXXIMEHKW-LJWNLINESA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Endomorphin-2
参考文献 for Endomorphin-2
参考文献是支持产品生物活性的出版物。
Chapman et al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537 PMID: 9422796
Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962
Harrison et al (1998) Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19 749 PMID: 9622031
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409
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关键词: Endomorphin-2, Endomorphin-2 supplier, Potent, selective, μ-opioid, mu-opioid, agonists, MOP, Receptors, OP3, Mu, Opioid, 1056, Tocris Bioscience
1 篇 Endomorphin-2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Endomorphin-2 的部分引用包括：
Garzón et al (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology 29 1091 PMID: 14997173
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