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Enoximone

Cat. No. 1693 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PDE3 inhibitor
化学名： 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Enoximone

Enoximone is an inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.

技术数据 for Enoximone

分子量 248.3
公式 C12H12N2O2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 77671-31-9
PubChem ID 53708
InChI Key ZJKNESGOIKRXQY-UHFFFAOYSA-N
Smiles CC(NC(N2)=O)=C2C(C1=CC=C(SC)C=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Enoximone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.83 100

制备储备液 for Enoximone

以下数据基于产品分子量 248.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

Molarity Calculator

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参考文献 for Enoximone

参考文献是支持产品生物活性的出版物。

Jung et al (2005) Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o J.Pharmacol.Exp.Ther. 312 517 PMID: 15550574

Pacher and Stanek (1999) Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1 263 PMID: 10935673

Vroom et al (1996) Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 76 122 PMID: 8672353

If you know of a relevant reference for Enoximone, please let us know.

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关键词: Enoximone, Enoximone supplier, phosphodiesterases, pde3, pdeIII, inhibitors, inhibits, Phosphodiesterases, 1693, Tocris Bioscience

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