EO 1428

Cat. No. 2908 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of p38α and p38β₂

化学名： (2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for EO 1428

EO 1428 is a selective inhibitor of p38α and p38β₂ that displays no activity at p38γ, p38δ, ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC₅₀ values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis.

化合物库 for EO 1428

EO 1428 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for EO 1428

分子量	415.71
公式	C₂₀H₁₆BrClN₂O
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	321351-00-2
PubChem ID	9801969
InChI Key	HDCLCHNAEZNGNV-UHFFFAOYSA-N
Smiles	CC1=CC=CC=C1C(C2=CC=C(NC3=C(N)C=C(Br)C=C3)C=C2Cl)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EO 1428

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	41.57	100
	ethanol	20.79	50

制备储备液 for EO 1428

以下数据基于产品分子量 415.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.03 mL	24.06 mL
5 mM	0.48 mL	2.41 mL	4.81 mL
10 mM	0.24 mL	1.2 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for EO 1428

分析证书/产品说明书

化学品安全技术说明书

参考文献 for EO 1428

参考文献是支持产品生物活性的出版物。

Ottosen et al (2003) Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J.Med.Chem. 46 5651 PMID: 14667219

If you know of a relevant reference for EO 1428, please let us know.

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查看全部 p38 MAPK Inhibitors

关键词: EO 1428, EO 1428 supplier, Selective, inhibitors, inhibits, p38α, p38alpha, p38β2, p38β, p38beta2, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, EO1428, p38, 2908, Tocris Bioscience

1 篇 EO 1428 的引用文献

引用文献是使用了 Tocris 产品的出版物。 EO 1428 的部分引用包括：

Jones et al (2018) Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Sci Signal 11 PMID: 29511118

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for EO 1428

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.