Erastin

Cat. No. 5449 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Mitochondrial VDAC modulator; also Ferroptosis activator

化学名： 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Erastin

Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

化合物库 for Erastin

Erastin is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Erastin

分子量	547.04
公式	C₃₀H₃₁ClN₄O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	571203-78-6
PubChem ID	11214940
InChI Key	BKQFRNYHFIQEKN-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC=C1N=C(C(N4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)C)N2C3=C(OCC)C=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Erastin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	10.94	20

制备储备液 for Erastin

以下数据基于产品分子量 547.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	9.14 mL	45.7 mL	91.4 mL
1 mM	1.83 mL	9.14 mL	18.28 mL
2 mM	0.91 mL	4.57 mL	9.14 mL
10 mM	0.18 mL	0.91 mL	1.83 mL

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产品说明书 for Erastin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Erastin

参考文献是支持产品生物活性的出版物。

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586

Yagoda et al (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 864 PMID: 17568748

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970

If you know of a relevant reference for Erastin, please let us know.

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